What Are Antibody-Drug Conjugates?
As mentioned previously, this antibody drug conjugate are created as a form of targeted therapy. This ADC manufacturing includes a process wherein complex molecules composed of an antibody or an antibody fragment which is linked via a stable, chemical, linker with labile bonds, to a biological active payload or drug. In reality, antibody drug conjugates are examples of bioconjugates and immunoconjugates. These loaded antibodies are designed in such a manner where they selectively deliver lethal cargoes to the affected cells providing a sustained clinical benefit, while ensuring minimum systemic toxicity
How Does It Work?
In the ADC manufacturing process, the antibody drug is linked with biological active drug or payload to target specific cell markers or proteins that cause the illness or disease. The antibodies track these proteins down in the body and attach themselves to the surface of these markers. This prompts a biochemical reaction between the antibody and the target protein, which in turn triggers a signal in the affecting cell. Consequently, the cell then absorbs or internalizes the antibody together with the biological active drug, thus neutralizing it. The antibody drug conjugates in clinical trials have proven to result in lower side effects and gives a wider therapeutic window as compared to other chemotherapeutic agents. However, a stable link between the antibody and biological active drug agent is a crucial aspect of an ADC.
What Is The Function Of A Linker In This Drug?
These linkers are based on chemical motifs, which contribute to the control of the delivery of the biological active drug agent to the targeted cell. Cleavable and non - cleavable types of linkers have been proven to be safely effective in the antibody drug conjugates in clinical trials. A non-cleavable linker keeps the drug within the cell, wherein the entire antibody, linker and the biological active drug enter the targeted cell where the antibody is degraded to the level of an amino acid. The resulting complex becomes an active drug. The cleavable linkers are catalysed by enzymes in the targeted cell where it releases the biological active drug agent. Through this process, the cleavable linker can escape from the targeted cell and, in a process called â€śbystander killing,â€ť attack neighbouring affected cells.
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Article Added on Thursday, March 31, 2016
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