Free Articles  >>  Legal >>  Page 395  >> 

Trasylol Kidney Damage Side Effects

Bayer's Trasylol problems are growing following increasing reports of the drug's side effects. Trasylol has recently been linked to a higher risk of kidney damage, heart attack, and death in the five years following a patient undergoing bypass heart surgery. In 1993 Trasylol (Aprotinin) was approved by the Federal Drug Administration. Aprotinin is manufactured by Bayer under the brand name Trasylol. Over the past several years Trasylol sales continued to increase even though studies indicated serious Trasylol kidney damage side effects.

Most heart surgery patients don't know if they were given Trasylol during their open heart surgery. Many patients suffering from Trasylol kidney damage side effects don't know if they were given Trasylol during their surgery because the surgeon made the decision whether to administer the drug to stop excessive bleeding during surgery.

Trasylol affects the way in which blood clots. It is given to open heart surgery patients to prevent excessive bleeding side effects. Trasylol is mainly used during repeat coronary artery bypass surgery to reduce the amount of bleeding both during and after surgery. The drug has been in use for 13 years and a million patients have received it. One of the most serious complications for bypass surgery patients is excessive bleeding. Clotting medications such as Trasylol reduce the amount of blood transfusion needed during surgery. In 2006 The New England Journal of Medicine (NEJM) published a study that reported Trasylol problems with an increased risk of developing heart failure, kidney damage, myocardial infarction, and stroke in bypass heart surgery patients.

On September 21, 2006 the FDA's Cardiovascular and Renal Drug Advisory Committee met to evaluate current data regarding Trasylol side effects. On September 29, 2006, the FDA issued a public health advisory stating that it had new information that Bayer failed to disclose an earlier study that it had conducted involving 67,000 heart surgery patients. Preliminary review of this study suggested that Trasylol side effects included higher risks for stroke, congestive heart failure, kidney damage, and death. Bayer failed to disclose this study during the Advisory Committee on September 21, 2006.

Dr. Dennis Mangano, the lead author of the NEJM Trasylol side effects study, has noted that Trasylol problems occurred more frequently than those linked with the drug Vioxx. Dr. Mangano relates, "In fact our findings raise even more troubling concerns, for:

(1) aprotinin has been on the market for three times as long as Vioxx, yet few comprehensive safety studies have been conducted since approval;

(2) the life-threatening complications with aprotinin found here occurred far more frequently than those with Vioxx; and

(3) far less expensive generic alternatives to aprotinin which are equally effective in limiting bleeding have been available, but have been underused."

The observational study concluded, "Our findings raise serious concerns regarding the safety of an approved drug intended to limit blood loss in at-risk patients undergoing surgery." Mangano related his opinion regarding the ongoing use of Trasylol, stating "In good conscience, I could not administer (Trasylol) to this group of patients, especially given the availability of safer alternatives." Trasylol problems continue to be studied and the FDA is monitoring Trasylol kidney damage side effects and advising physicians to consider limiting the drug's use.
About Author Steve Fields :

Steve Fields <a href="" target="_blank"></a>

Article Source:
Article Url:

Article Added on Thursday, April 26, 2007
Other Articles by Steve Fields

Permax Heart Valve Damage
Evidence of Permax heart valve damage has increased following a new study published in the March 2007 issue of the medical journal Archives of Neurology. This study provides further support of the problems linked to Permax. Heart valve damage was found to increase with long-term use of the drug. The purpose of this study was to compare Permax patients with those treated with the drugs Mirapex and Requip. The Federal Drug Administration (FDA) first became aware of Permax heart valve injury...

Gadolinium Mri
Gadolinium MRI and risk factors for the debilitating disease nephrogenic systemic fibrosis (NSF) are currently being investigated by the Food and Drug Administration (FDA). An MRI with gadolinium is a type of MRI that uses a contrast agent with special magnetic properties to help increase the visibility of organs and tissues. Since its approval in 1988, MRI with gadolinium has been administered to millions of patients. Magnetic resonance imaging (MRI) is a diagnostic study that has been used...

Trileptal Side Effects
Trileptal side effects including Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) have been added to the drugs warning label following reports of an increased risk of severe skin conditions in patients. Trileptal can cause allergic reactions including skin reactions that in certain cases can be life-threatening. Trileptal was approved by the Federal Drug Administration (FDA) in January 2000. Trileptal, an anticonvulsant or antiepileptic drug (AED), was approved for use as...

Nuvaring Birth Control Information
NuvaRing birth control is a combination hormonal contraceptive. It is manufactured by Organon USA. NuvaRing is a polyethylene vinyl acetate ring around 2 inches in diameter. It is worn in the vagina for three weeks and then removed for one week. The ring contains a combination of the hormones estrogen and progestin. NuvaRing birth control slowly releases the hormones into the bloodstream. The progestin is absorbed and prevents the ovary from releasing an egg. In addition, the uterine lining...

Publishers / Webmasters
Article ID: 60265
DELINK URL from Authors Bio
REMOVE Article
Tell A Friend
Leave A Comment!
Download this article in PDF
Report Article!
Search through all the articles:

405 Users Online !
Related Articles:
Latest Articles:
Legal >> Top 50 Articles on Legal
Category - >
Advertising Advice Affiliate Programs Automobiles
Be Your Own Mentor Careers Communication Consumers
CopyWriting Crime Domain Names DoT com Entrepreneur Corner
Ebooks Ecommerce Education Email
Entertainment Environment Family Finance And Business
Food & Drink Gardening Health & Fitness Hobbies
Home Business Home Improvement Humour House Holds
Internet And Computers Kiddos and Teens Legal Matters Mail Order
Management Marketing Marriage MetaPhysical
Motivational MultiMedia Multi Level Marketing NewsLetters
Pets Psychology Religion Parenting
Politics Sales Science Search Engine Optimization
Site Promotion Sports Technology Travel
Web Development Web Hosting WeightLoss Women's Corner
Writing Miscellaneous Articles Real Estate Arts And Crafts

Disclaimer: The information presented and opinions expressed in the articles are those of the authors
and do not necessarily represent the views of and/or its owners.

Copyright AwareINDIA. All rights reserved || Privacy Policy || Terms Of Use || Author Guidelines || Free Articles
FAQs Link To Us || Submit An Article || Free Downloads|| Contact Us || Site Map  || Advertise with Us ||
Click here for Special webhosting packages for visitors of this website only!
Vastu Shastra

Bulk Email Solutions India Provided By AwareIndia

Company IDS