The pathognomonic sign for this condition is the presence of varicosities in the anal area, be it internal or external. These swollen veins are usually accompanied by pain, inflammation, swelling at the affected area, and, in over half of the cases, bleeding. Not all of these symptoms are present in every case, but these are the ones that are most likely to appear.
To address the pressing concerns of hemorrhoids, most doctors recommend a daily hot sitz bath, accompanied by dietary changes that aid in preventing constipation. Some opt to take the pharmacologic route and apply a potent topical ointment to the area at the prescribed frequency and interval. The most commonly used medications are Polysporin and Neosporin. Both are brand names of topical ointments with antibacterial properties. Some patients report a superiority of one product over the other. However, they present little precedent fact as patients tend to judge based on firsthand experience of drug usage. In order to gain a more scientific premise, let us compare the two:
Being the more widely known of the two, Neosporin is recognized as a triple antibiotic ointment. It is usually applied to breaks in the skin, specifically open sores, to prevent infection and to kill the surrounding bacteria. These drug actions allow speedier healing of the affected area and alleviated inflammation.
When applied to the affected area, one of its components, neomycin, is actively transported through the external membranous wall of the bacterial cell. Once it has infiltrated the microorganism, it binds to a certain component of the cellâ€™s ribosomes. This allows the drug to hinder the delivery of messages between the ribonucleic acid (RNA) and the 30S subunit, which prevents the synthesis or protein in the cell. Because of this, its RNA component may be misread and may result in the production of non functional proteins. Its polyribosomes are then torn and rendered unable to synthesize protein. This process kills off the bacteria.
This drug was crafted to have similar effects to Neomycin. Its mechanism of action involves the prevention of potential bacterial infections by inhibiting their growth and development in the area. As of late, reports of hypersensitivity of this drug have been rare.
Similar to Neosporin, its bacitracin component disrupts the regenerative process of the bacterial cellâ€™s phospholipid receptors, which in turn prevents synthesis of the bacterial cell wall.
Polysporin and Neosporin both have the following components: bacitracin and polymixin B sulfate. The main difference between the two is the presence of the component neomycin; Neosporin has it whereas Polysporin does not. This ingredient is responsible for the hypersensitivity reaction in some patients when they use Neosporin.
In conclusion, there is no â€śsuperior drugâ€ť between the two. They are both equally effective in relieving the inflammation and pain caused by hemorrhoids. However, more precaution is to be used with Neosporin as it may cause an allergic reaction. In such an event, Polysporin may be used instead.
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Article Added on Saturday, February 3, 2018
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